Drug combinations with substituted diaryl ureas for the...

A - Human Necessities – 61 – K

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Details

A61K 31/44 (2006.01) A61K 31/337 (2006.01) A61K 31/555 (2006.01) A61K 33/24 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2652926

The present invention relates to drug combinations and pharmaceutical compositions for treating cancer such as non-small cell lung carcinoma, said combination comprising (1) at least one substituted-diaryl urea such as BAY 43-9006, (2) at least one taxane such as Paclitaxel (Taxol®), Docetaxel (Taxotere®) and AbraxaneTM and (3) at least one platinum complex antineoplastic nucleic acid binding agent such as carboplatin (Paraplatin®), oxaplatin (Eloxatin®) and cisplatin (Platinol®), where any of these components can be present in the form of a pharmaceutically acceptable salt or other derivative thereof.

La présente invention concerne des associations de médicaments et des compositions pharmaceutiques destinées au traitement du cancer, tel que le cancer bronchopulmonaire "non à petites cellules". Cette association comprend: 1) au moins une urée de diaryle substituée, telle que BAY 43-9006; 2) au moins un taxane, tel que Paclitaxel (Taxol®), Docetaxel (Taxotere®) et AbraxaneTM; et 3) au moins un agent de liaison à l'acide nucléique antinéoplasique d'un complexe de platine, tel que carboplatine (Paraplatin®), oxaplatine (Eloxatin®) et cisplatine (Platinol®), l'un quelconque de ces composants pouvant être présent sous la forme d'un sel pharmaceutiquement acceptable ou d'un autre dérivé dudit sel.

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