Drug-complex microparticles and methods of making/using same

Details Drug-complex microparticles and methods of making/using same Drug-complex microparticles and methods of making/using same

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/48 (2006.01) A61K 31/473 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2480403

Oral drug complex microparticles containing: a pharmaceutical active having a nitrogen moiety and an anionic methacrylic acid copolymer; wherein the oral drug complex micropaticles resist dissolution or dissociation upon exposure to saliva, but which rapidly dissociate in gastric acid and which rapidly dissolve in intestinal fluid. Oral drug delivery devices containing said oral drug complex microparticles are provided. Processes for producing said oral drug complex microparticles and methods for treating patients including administering said oral drug delivery devices thereto are also provided.

L'invention concerne des microparticules complexe-médicament contenant un principe actif pharmaceutique à groupe azoté et un copolymère anionique d'acide méthacrylique. Les microparticules complexe-médicament orales résistent à la dissolution ou à la dissociation lorsqu'elles sont exposées à la salive, mais se dissocient rapidement dans l'acide gastrique et se dissolvent rapidement dans le fluide intestinal. L'invention concerne aussi des dispositifs oraux d'administration de médicament contenant ces microparticules complexe-médicament. Elle concerne encore des procédés de production des microparticules complexe-médicament orales ainsi que des méthodes de traitement de patients comprenant l'administration des dispositifs oraux d'administration de médicament.

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