Drug composition containing nucleic acid copolymer

Details Drug composition containing nucleic acid copolymer Drug composition containing nucleic acid copolymer

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61K 9/127 (2006.01) A61K 31/7105 (2006.01) A61K 47/24 (2006.01) A61K 47/44 (2006.01) A61P 35/00 (2006.01) C07C 229/12 (2006.01) C07C 237/08 (2006.01) C07C 271/16 (2006.01) C07C 271/20 (2006.01) C07C 279/20 (2006.01) C07C 333/04 (2006.01) C07D 295/13 (2006.01) C07F 9/40 (2006.01)

Patent

CA 2156289

This invention has for its object to insure an effective utilization of single-stranded nucleic acid copolymers, particularly poly(adenylic acid-uridylic acid), and to provide a pharmaceutical composition having antitumor activity. The invention typically relates to a pharmaceutical composition comprising a lipid device such as Lipofectin (trademark), 3-O-(4- dimethylaminobutanoyl)-1,2-O-dioleylgycerol, 3-O-(2-dimethylamino- ethyl)carbamoyl-1,2-O-dioleylglycerol, 3-O-(2-diethylaminoethyl) carbamoyl-1,2-O-dioleylgycerol, or 2-O-(2-diethylaminoethyl)carbamoyl- 1,3-O-dioleoylglycerol and poly(adenylic acid-uridylic acid).

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