Drug composition cytotoxic for pancreatic cancer cells

A - Human Necessities – 61 – K

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31/5377 (2006.01) A61K 31/196 (2006.01) A61K 31/277 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) A61K 31/7068 (2006.01)

Patent

CA 2745265

The invention describes a cytotoxic composition containing a drug combination targeting two or more functional elements in pancreatic cancer cells, the functional elements comprising EGFR or Src and Stat3 or Jaks. Preferred drugs in the drug combination are selected from ZD and S31-201, Das and S31-201, ZD and AG490, Das and AG490, and combinations thereof. In a preferred embodiment of the invention, the drug combination further includes a nucleoside analog inhibitory for DNA replication, for example, Gem-citabine. Disclosed is also a method of cytotoxically affecting pancreatic cancer cells using the described drug combination. A method of making the cytotoxic composition is additionally described.

La présente invention concerne une composition cytotoxique contenant une association de médicaments ciblant deux éléments fonctionnels ou plus dans des cellules de cancer pancréatique, les éléments fonctionnels comprenant EGFR ou Src et Stat3 ou Jaks. Des médicaments préférés dans lassociation de médicaments sont choisis parmi ZD et S3I-201, Das et S3I-201, ZD et AG490, Das et AG490, et des combinaisons de ceux-ci. Dans un mode de réalisation préféré de linvention, lassociation de médicaments comprend en outre un analogue de nucléoside inhibiteur de réplication dADN, par exemple, la gemcitabine. La présente invention concerne en outre un procédé daffection cytotoxique de cellules de cancer pancréatiques utilisant lassociation de médicaments décrite. La présente invention concerne en outre un procédé de préparation de la composition cytotoxique.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Drug composition cytotoxic for pancreatic cancer cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug composition cytotoxic for pancreatic cancer cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug composition cytotoxic for pancreatic cancer cells will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1468250

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.