Drug conjugates and methods of designing the same

Details Drug conjugates and methods of designing the same Drug conjugates and methods of designing the same

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2382202

The invention relates to drug conjugates and methods of their design. One embodiment of the invention is directed to a method of designing vector-linker- pharmacophore ("VLP") conjugates that is generally applicable to a wide variety of vectors, linkers, and pharmacophores. The invention also encompasses a method of improving the delivery of a pharmacophore to a patient, as well as a method of improving the therapeutic efficacy of a pharmacophore and a method of decreasing the toxicity of a pharmacophore. A method of increasing the concentration of a pharmacophore in a cell is further encompassed by the invention.

La présente invention concerne des conjugués de médicaments et leurs procédés de préparation. Un des modes de réalisation de cette invention concerne un procédé de préparation des conjugués VLP (vecteur-liant-pharmacophore) pouvant être généralement appliqué à une grande variété de vecteurs, liants, et pharmacophores. En outre, cette invention concerne un procédé d'amélioration de l'administration d'un pharmacophore à un patient, ainsi qu'un procédé d'amélioration de l'efficacité thérapeutique d'un pharmacophore et un procédé de réduction de la toxicité d'un pharmacophore. Par ailleurs, cette invention concerne un procédé d'augmentation de la concentration d'un pharmacophore dans une cellule.

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