Drug conjugates and their use for treating cancer, an...

Details Drug conjugates and their use for treating cancer, an... Drug conjugates and their use for treating cancer, an...

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2494105

Drug-Linker-Ligand Conjugates are disclosed in which a Drug is linked to a Ligand via a peptide-based Linker unit. In one embodiment, the Ligand is an Antibody. Drug-Linker compounds and Drug compounds are also disclosed. Methods for treating cancer, an autoimmune disease or an infectious disease using the compounds and compositions of the invention are also disclosed.

L'invention concerne des conjugués médicament-lieur-ligand dans lesquels un médicament est lié à un ligand par le biais d'une unité lieuse à base de peptides. Dans un mode de réalisation, le ligand est un anticorps. L'invention concerne en outre des composés de médicaments-lieurs et des composés de médicaments, ainsi que des procédés de traitement du cancer, d'une maladie auto-immune ou d'une maladie infectieuse au moyen des composés et compositions selon l'invention.

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