Drug delivering substance containing polyalkylene glycol and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 45/00 (2006.01) A61K 47/24 (2006.01) A61K 47/34 (2006.01) A61K 49/00 (2006.01) A61P 9/00 (2006.01) A61P 9/08 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 27/02 (2006.01) A61P 27/06 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2404737

Excellent transporters which enable a drug to efficaciously exist in vivo over a long time are designed and thus a drug delivery system is constructed by using these transporters. The transporters are prepared by forming a covalent bond by reacting polyalkylene glycol or its reactive derivative with a phospholipid and a drug. When systemically or topically administered, these transporters are retained at a target site in vivo, thereby making it possible to achieve a sustained drug effect over a long time by a single administration.

La présente invention concerne d'excellents transporteurs qui permettent à un médicament de rester efficace, <i>in vivo</i> sur une longue période. Selon cette invention, un système de distribution de médicament est établi par utilisation de ces transporteurs. Ces transporteurs sont préparés par formation d'une liaison covalente, induite par réaction de polyalkylène glycol ou d'un dérivé réactif de celui-ci avec un phospholipide et un médicament. Lorsqu'ils sont administrés par voie systémique ou topique, ces transporteurs sont retenus au niveau d'un site cible, <i>in vivo</i>, ce qui permet d'obtenir un effet médicamenteux soutenu, sur une longue période, au moyen d'une administration unique.

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