Drug delivery device and method for bi-directional drug...

A - Human Necessities – 61 – M

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A61M 31/00 (2006.01) A61L 27/54 (2006.01) A61M 35/00 (2006.01)

Patent

CA 2528166

A drug delivery device is provided with openings for directional delivery of a plurality of therapeutic agents to blood vessels or other lumens or organs. In particular, the invention relates to the delivery of different therapeutic agents, different quantities of therapeutic agents, or different release profiles of the same or different therapeutic agents in different directions from the drug delivery device. The invention is useful, for example, for delivering antirestenotic, antithrombotic, antiplatelet, antiproliferative, antineoplastic, immunosuppressive, angiogenic, anti~inflammatory, or antiangiogenic agents and/or vasodilators to a blood vessel. In one embodiment, antiproliferative, antineoplastic, angiogenic, antiangiogenic, anti~inflammatory, and/or antirestenotic agents are delivered to the wall of a blood vessel and antithrombotic agents, antiplatelet agents, and/or vasodilators are delivered to the lumen of a blood vessel.

L'invention concerne un dispositif d'administration de médicaments pourvu d'ouvertures destinées à l'administration directionnelle d'une pluralité d'agents thérapeutiques qui doivent arriver jusqu'aux vaisseaux sanguins ou à des lumières ou organes. L'invention concerne notamment l'administration de divers agents thérapeutiques, de quantités variées d'agents thérapeutiques ou de profils de libération de différents agents thérapeutiques identiques ou différents dans de différentes directions par rapport au dispositif d'administration de médicaments. L'invention peut s'utiliser, par exemple, dans l'administration dans un vaisseau sanguin d'agents antirésténotiques, antithrombotiques, antiplaquettaires, antiprolifératifs, antinéoplasiques, immunosuppresseurs, angiogéniques, anti-inflammatoires ou anti-angiogéniques et/ou vasodilatateurs. Dans un mode de réalisation, les agents antirésténotiques, antiprolifératifs, antinéoplasiques, angiogéniques, anti-angiogéniques, anti-inflammatoires ou antirésténotiques sont administrés jusqu'à la paroi d'un vaisseau sanguin, et les agents antithrombotiques, antiplaquettaires et/ou vasodilatateurs sont administrés jusqu'à la lumière d'un vaisseau sanguin.

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