Drug delivery from embolic agents

Details Drug delivery from embolic agents Drug delivery from embolic agents

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/00 (2006.01) A61K 31/192 (2006.01) A61K 31/196 (2006.01) A61K 31/365 (2006.01) A61K 31/40 (2006.01) A61K 31/405 (2006.01) A61K 31/407 (2006.01) A61K 31/415 (2006.01) A61K 31/421 (2006.01) A61K 31/5415 (2006.01) A61K 31/60 (2006.01) A61K 31/603 (2006.01)

Patent

CA 2516736

A pharmaceutical composition for uterine fibroid embolisation comprises a polymer and, associated with the polymer in a releasable form, a COX inhibitor, e.g. a non-steroidal anti inflammatory drug, such as ibuprofen. The polymer is preferably in particulate form, such as in the form of microspheres. A suitable polymer is a crosslinked polyvinyl alcohol polymer formed by the copolymerisation of PVA macromer with other ethylenically unsaturated monomers. The composition provides a synergistic treatment for the symptoms of uterine fibroids, leading to size regression as well as pain relief.

L'invention concerne une composition pharmaceutique destinée à une embolisation de fibrome utérin et comprenant un polymère et, associé à ce polymère sous une forme libérable, un inhibiteur de COX, et notamment un médicament anti-inflammatoire non stéroïdien tel que l'ibuprofène. Le polymère se présente de préférence sous forme particulaire, et notamment sous la forme de microsphères. Un polymère approprié est un polymère d'alcool polyvinylique réticulé formé par copolymérisation d'un macromère de PVA avec d'autres monomères éthyléniquement insaturés. Cette composition permet d'obtenir un traitement synergique pour les symptômes des fibromes utérins, d'où une régression de taille ainsi qu'une atténuation de la douleur.

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