Drug delivery from rapid gelling polymer composition

A - Human Necessities – 61 – K

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A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 47/34 (2006.01)

Patent

CA 2511521

Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.

L'invention concerne des compositions permettant la libération d'un médicament à partir de compositions polymères à deux composants qui forment rapidement des liaisons covalentes lorsqu'ils sont mélangés. Ces compositions se prêtent particulièrement à diverses applications tissulaires, dans lesquelles une adhérence rapide aux tissus et la formation d'un gel sont souhaitables en association à la libération d'un médicament. Ces compositions peuvent être utilisées par exemple en tant qu'adhésifs tissulaires, pour la stimulation de l'hémostase, pour la fixation tissulaire, pour l'augmentation tissulaire et pour la prévention des adhérences en chirurgie.

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