Drug delivery matrices to enhance wound healing

Details Drug delivery matrices to enhance wound healing Drug delivery matrices to enhance wound healing

A - Human Necessities

61

L

A61L 24/10 (2006.01) A61L 24/00 (2006.01) A61L 27/22 (2006.01) A61L 27/54 (2006.01) A61L 31/04 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2445239

The invention provides a more efficient entrapment of bioactive molecules within a matrix for the controlled delivery of these compounds for therapeutic healing applications. The matrix may be formed of natural or synthetic compounds. The primary method of entrapment of the bioactive molecule is through precipitation of the bioactive molecule during gelation of the matrix, either in vitro or in vivo. The bioactive molecule is deglycosylated to reduce its effective solubility in the matrix to retain it more effectively within the matrix. Preferably the bioactive factors are deglycosylated members of the cystine knot growth factor superfamily, and particular within the TGF.beta. superfamily.

L'invention concerne une matrice permettant de mieux emprisonner les molécules bioactives destinées à être administrées de façon contrôlée dans des applications thérapeutiques de cicatrisation. Cette matrice peut être formée à partir de composés naturels ou synthétiques. Le procédé global permettant d'emprisonner la molécule bioactive dans la matrice consiste à précipiter la molécule bioactive durant la gélification de la matrice, soit in vitro, soit in vivo. La molécule bioactive est déglycosylée pour réduire sa solubilité effective dans la matrice et pour la retenir plus efficacement dans la matrice. De préférence, les facteurs bioactifs sont des éléments déglycosylés de la superfamille des facteurs de croissance à noeuds de cystine, et en particulier de la superfamille des TGF.beta.

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