Drug delivery porphyrin compositions and methods

Details Drug delivery porphyrin compositions and methods Drug delivery porphyrin compositions and methods

C - Chemistry, Metallurgy

07

K

C07K 14/795 (2006.01) A01M 5/06 (2006.01) A61K 9/127 (2006.01) A61K 31/40 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) C07F 5/02 (2006.01) C07F 5/05 (2006.01) A61K 43/00 (1990.01)

Patent

CA 2096841

A compound is described having structure (I) where R preferably is (a) and most preferably R3 is a closo-carborane and R2 is H, an alkyl or aryl having 1 to about 7 carbon atoms, or a physiologically acceptable salt. Compounds of the invention are useful in boron neutron capture therapy; photodynamic therapy, and other biomedical applications. One embodiment we have designated 2,4-bis-[.alpha., .beta.-(1,2-dicarbaclosododecaborane carboxy)ethyl]deuteroporphyrin (x), appears not to pass through the normal blood brain barrier, has excellent water solubility, and has been shown efficacious in boron neutron capture therapy in vivo against the KHJJ mammary carcinoma:

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