Drug delivery stent with extended in vivo drug release

Details Drug delivery stent with extended in vivo drug release Drug delivery stent with extended in vivo drug release

A - Human Necessities

61

F

A61F 2/00 (2006.01)

Patent

CA 2641662

A method for reducing the level of restenosis following a stent placement medical Intervention involves the continuous administration of a dose of an anti- restenotic agent , such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled and extended drug release profile for a period of at least 60 days in vivo. The in vivo release profile is determined by in vivo animai experiments involving implanting a series of stents in animals, explanting the stents from the animals at selected time points, and extracting remaining drug from the cxplanted stents.

La présente invention concerne un procédé pour la réduction du niveau de resténose suite à une intervention médicale pour le placement d'une prothèse endovasculaire comprenant l'administration en continu d'une dose d'agent anti-resténose, tel que le paclitaxel, depuis la prothèse endovasculaire vers le tissu vasculaire nécessitant un traitement pour une période d'au moins 60 jours in vivo. Le profil de libération in vivo est déterminé par des expériences in vivo sur des animauxcomprenant l'implantation d'une série de prothèses endovasculaires chez des animaux, l'explantation des prothèses endovasculaires à partir des animaux à des points temporels sélectionnés, et l'extraction de médicament résiduel à partir des prothèses endovasculaires explantées.

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