Drug delivery system

A - Human Necessities – 61 – L

Patent

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Details

A61L 31/00 (2006.01) A61F 2/82 (2006.01) A61K 9/51 (2006.01) A61K 45/00 (2006.01) A61P 9/10 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2710490

It is a main object of the present invention to provide a drug delivery system in which drugs can be changed or which can be recharged with drugs, which continuously delivers drugs at effective concentrations to local lesional sites in a body and allows the use of drugs for which it has thus far been difficult to achieve effective local concentrations for a variety of reasons and drugs which have been difficult to use due to adverse effects on tissues that are not sites of action. The present invention provides a drug delivery system comprising an indwelling medical device on which a biocompatible material having target molecules on its surface has been coated, and target-recognizing nanocarriers (e.g., bio-nanocapsules, liposomes, liposome preparations, and nanoparticles) in which drugs are encapsulated and which have target-recognizing molecules capable of specifically binding to the target molecules.

L'invention a pour objet de pourvoir à un système d'administration de médicament qui permet l'utilisation d'un médicament qui ne peut pratiquement pas établir de concentration topique efficace pour diverses raisons ou d'un médicament qui ne peut pratiquement pas être employé du fait qu'il a un effet secondaire sur un tissu autre que le site d'action, qui est capable d'administrer de façon continue un médicament à une concentration efficace à une lésion située dans le corps, et qui permet le changement ou la recharge du médicament. Le système d'administration de médicament comporte un dispositif médical devant être placé dans le corps. La surface dudit dispositif est revêtue d'un matériau biocompatible pourvu d'une molécule cible et d'un nanoporteur de reconnaissance de cible (une bionanocapsule, un liposome, une lipopréparation, une nanoparticule, ou autres) qui possède une molécule de reconnaissance de cible capable de se lier spécifiquement à la molécule cible telle que décrite ci-dessus, et qui est muni d'un médicament encapsulé dans celui-ci.

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