A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 25/10 (2006.01) A61F 2/06 (2006.01) A61K 9/00 (2006.01) A61K 38/49 (2006.01) A61K 48/00 (2006.01) A61L 29/08 (2006.01) A61L 29/14 (2006.01) A61L 29/16 (2006.01) A61L 31/14 (2006.01) A61L 31/16 (2006.01) A61M 29/02 (2006.01) A61F 2/00 (2006.01) A61M 16/04 (2006.01) A61M 25/00 (2006.01)
Patent
CA 2098984
The invention features a catheter (1) and methods for delivering drug to tissue at a desired location of the wall of a body lumen (2). The catheter (1) is constructed for insertion in a body lumen (2) and has a catheter shaft (3) and an expandable portion (4) mounted on the catheter shaft (3). The expandable portion (4) is expandable to a controlled pressure to fill the cross-section of the body lumen (2) and press against the wall (9) of the body lumen (2). In one embodiment, at least a portion of the exterior sur- face of the expandable portion (4) is defined by a coating (6) of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug (8) to be delivered to the tissue or plaque. The hydrogel po- lymer and drug (8) are selected to allow rapid release of a desired dosage of the drug (8) from the hydrogel polymer coating dur- ing compression of the hydrogel polymer coating against the wall (9) of the lumen (2) when the expandable portion (4) is ex- panded. In other embodiments the polymer is released from the expandable portion (4) in response to pressure, to coat the wall (9) of the body lumen (2).
Boston Scientific Corporation
Oyen Wiggs Green & Mutala Llp
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