Drug delivery system for bioadhesion to a vulvovaginal surface

A - Human Necessities – 61 – K

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Details

A61K 9/107 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/7036 (2006.01) A61K 45/06 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2635994

A pharmaceutical composition comprises a first active {e.g., antibacterial) agent and a second (e.g., antifungal) active agent, and comprises a component that is adapted for bioadhesion to a vulvovaginal surface. The composition provides differential release of the active agents at such a surface, wherein the second active agent exhibits a release profile that is substantially delayed, extended and/or inverted relative to the release profile of the first active agent.

L'invention concerne une composition pharmaceutique contenant un premier agent actif (par exemple, antibactérien) et un second agent actif (par exemple antifongique), et contenant un composant de bioadhésion à une surface vulvo-vaginale. Cette composition permet une libération différentielle des agents actifs au niveau d'une telle surface, le second agent actif présentant un profil de libération sensiblement retardé, étendu et/ou inversé par rapport au profil de libération du premier agent actif.

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