Drug delivery system for hydrophobic drugs

Details Drug delivery system for hydrophobic drugs Drug delivery system for hydrophobic drugs

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 9/127 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2439500

Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Suchmicroaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.

L'invention concerne des compositions comprenant des micro-agrégats contenant des médicaments hydrophobes, ainsi que leurs procédés de production. De tels micro-agrégats peuvent comprendre des structures micellaires ou des combinaisons de celles-ci avec des liposomes, et ils constituent un véhicule d'administration efficace pour un agent hydrophobe. Des procédés permettant de produire ces micro-agrégats impliquent l'utilisation de composés lipidiques préférés et des conditions de traitement favorisant la production de petits agrégats pour l'obtention d'une stérilisation des filtres améliorée.

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