A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/08 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 31/573 (2006.01) A61K 47/06 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2476935
It is intended to provide an excellent drug delivery system toward the posterior segment of eyeball. A subconjunctival injection containing fine grains containing a drug which enables the migration of the drug into the posterior chamber of eyeball. By the subconjunctival administration of the drug-containing fine grains, the drug can be efficiently delivered into the posterior chamber of eyeball (retina, choroid, optic nerve, etc.) while scarcely injuring eye tissues. It is favorable that these fine grains are made of a synthetic biodegradable polymer and have an average grain size of from 50 nm to 150 µm and the drug is uniformly dispersed in the fine grains. Preferable examples of the drug include anti-inflammatory agents, immunosuppressants, antiviral agents, anticancer agents, angiogenesis inhibitors, optic nerve protecting agents, antibacterial agents or antifungal agents.
L'invention concerne la production d'un excellent systme d'administration de m~dicament au niveau du segment post~rieur d'un oeil. Une injection subconjonctivale contient des grains fins renfermant un m~dicament permettant la migration du m~dicament dans la chambre post~rieure d'un oeil. Par administration subconjonctivale des grains fins renfermant des m~dicaments, le m~dicament peut efficacement Útre administr~ dans la chambre post~rieure d'un oeil (r~tine, choro~de, nerf optique, etc.) en ne blessant pratiquement pas les tissus oculaires. Il est pr~f~rable que ces grains fins soient fabriqu~s ~ partir de polymre biod~gradable synth~tique et qu'ils possdent une dimension de grain moyenne comprise entre 50 nm et 150 µm et que le m~dicament soit r~parti de fa×on uniforme dans les grains fins. Parmi les exemples pr~f~r~s du m~dicament, on peut citer des agents anti-inflammatoires, des immunosuppresseurs, des agents antiviraux, des agents anti-cancer, des inhibiteurs d'angiog~nse, des agents de protection du nerf optique, des agents antibact~riens ou des agents antifongiques.
Kuwano Mitsuaki
Yamada Kazuhito
Fetherstonhaugh & Co.
Santen Pharmaceutical Co. Ltd.
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