A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/22 (2006.01) A61K 9/20 (2006.01) A61K 9/24 (2006.01) A61K 9/28 (2006.01) A61K 9/30 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01)
Patent
CA 2448558
The invention is directed to a drug delivery device for controlled release of a drug, comprising a core that has a cylindrical plug embedded therein; and a coating that at least partially surrounds the core. The core is comprised of a drug and excipients. The coating surrounding the core is essentially impermeable to the drug. The cylindrical plug, which is embedded in the core, may be hollow or solid. The drug delivery device enables zero-order drug release profiles as well as more complicated release profiles to be obtained. The invention is also directed to a method of making the drug delivery device.
La présente invention concerne un système d'administration de médicament permettant une libération contrôlée d'un médicament, comprenant un coeur dans lequel est noyé un élément d'insertion cylindrique, et un revêtement qui entoure au moins partiellement le coeur. Le coeur comprend un médicament et des excipients. Le revêtement entourant le coeur est sensiblement imperméable au médicament. L'élément d'insertion cylindrique qui est noyé dans le coeur, peut être creux ou solide. Le système d'administration de médicament permet d'obtenir des profils de libération de degré zéro ainsi que des profiles de libération plus complexes. L'invention a également pour objet un procédé destiné à la production du système d'administration de médicament.
Fleshner-Barak Moshe
Lerner E. Itzhak
Rosenberger Vered
Heenan Blaikie Llp
Teva Pharmaceutical Industries Ltd.
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