Drug delivery system including a drug transport enhancement...

A - Human Necessities – 61 – M

Patent

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A61M 37/00 (2006.01) A61B 17/22 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2294202

A drug delivery system includes a container (174) in which a shock wave is generated for transmission to a target material, and a drug enhancement mechanism for enhancing absorption of a medicament by the target material. The container (174) includes a shock generating chamber (322), a shock tube (308) coupled to the shock generating chamber (322) having a membrane (310) mounted to a distal end through which the shock wave is transmitted, and a shock wave generating mechanism disposed within the shock generating chamber (322). Illustrative drug enhancement mechanisms include ultrasound, iontophoresis, high-pressure gradients, mechanical vibration, and surfactant. The shock generating mechanism may take various forms, including a rapidly openness divider and electric discharge.

Un système d'administration de médicament comprend un récipient (174) dans lequel une onde de choc est produite afin d'être transmise à une matière cible, et un mécanisme d'activation du médicament destiné à activer l'absorption d'un médicament par la matière cible. Le récipient (174) comprend une chambre (322) génératrice de choc, un tube (308) de choc couplé à la chambre (322) génératrice de choc présentant une membrane (310) montée sur une extrémité distale par laquelle l'onde de choc est transmise, et un mécanisme générateur d'onde de choc disposé à l'intérieur de la chambre (322) génératrice de choc. Les mécanismes d'activation de médicament pris à titre d'exemple comprennent les ultrasons, l'iontophorèse, les gradients à haute pression, les vibrations mécaniques et un tensioactif. Le mécanisme générateur de choc peut adopter diverses formes, notamment une séparation à ouverture rapide et une décharge électrique.

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