Drug delivery targeting by rod deformation

Details Drug delivery targeting by rod deformation Drug delivery targeting by rod deformation

A - Human Necessities

61

N

A61N 2/00 (2006.01) A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61M 15/00 (2006.01)

Patent

CA 2516968

This paper presents a model to externally induce deformation of a fibre introduced inside a human lung. The fibre contains ferromagnetic materials and has a cross-section of 0.4x0.22 µm and length of 20 µm. The fibre heating is achieved by applying an external high frequency magnetic field (2.6kA/m, 1.0MHz) to induce eddy currents in the ferromagnetic materials. Prediction of the thermal bending of the fibre requires multi physics modeling. A finite element model is constructed to calculate the electromagnetic energy dissipation within the fibre. The deposited energy is coupled to a heat- transfer model to calculate the temperature rise. The distribution of temperature inside the fibre then allows prediction of fibre deformation. A 2.2 µm tip displacement is achieved in the solid mechanic analysis. This is the first attempt to use thermal heating induced by a high frequency oscillatory magnetic field to cause deformation of a foreign fibre in the human body. PACS: 46.70.Hg; 41.20.Gz; 62.20.Fe; 87.80.Rb Keywords: Fibre deformation, eddy current, lung, ferromagnetic material

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