Drug delivery through hydrogel plugs

Details Drug delivery through hydrogel plugs Drug delivery through hydrogel plugs

A - Human Necessities

61

K

A61K 9/10 (2006.01) A61F 9/00 (2006.01) A61K 31/4709 (2006.01) A61K 31/5575 (2006.01) A61L 31/04 (2006.01) A61L 31/16 (2006.01) A61M 31/00 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2750242

An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.

Un mode de réalisation de la présente invention concerne une prothèse médicale destinée à bloquer ou réduire l'écoulement lacrymal dans un punctum ou un canaliculus d'un il humain et à délivrer un médicament à l'il qui comprend un hydrogel de polymère hydrophile synthétique et réticulé de manière covalente ayant des dimensions lui permettant de traverser un puncta lacrimali, l'hydrogel déshydraté absorbant l'eau physiologique pour que sa largeur en coupe gonfle d'au moins 1 mm et qu'il se conforme à un canaliculus, un agent thérapeutique destiné à être libéré dans l'il étant dispersé dans l'hydrogel, l'hydrogel ayant une teneur en eau d'au moins environ 50 % en poids ou en volume lorsqu'on le laisse s'hydrater totalement in vitro dans une solution saline.

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