Drug-delivery vehicles based on reversed liquid crystalline...

Details Drug-delivery vehicles based on reversed liquid crystalline... Drug-delivery vehicles based on reversed liquid crystalline...

A - Human Necessities

61

K

A61K 9/14 (2006.01) B01J 20/22 (2006.01)

Patent

CA 2541811

Uncoated particles of reversed cubic phase or reversed hexagonal phase material containing an active disposed within are provided. The uncoated particles have an ionic charge that is sufficient to stabilize them in dispersion in a liquid, e.g. a polar solvent. The active that is disposed within the particles may be, for example, a pharmaceutical or nutriceutical compound. The invention also contemplates drug formulations containing reversed hexagonal and reversed cubic phases that can be applied to significantly increase the duration of action of the drug and/or provide the same duration and efficiency at a significantly lower dose.

La présente invention concerne des particules non enrobées d'un matériau à phase cubique inversée ou à phase hexagonale inversée contenant un principe actif. Les particules non enrobées décrites dans cette invention présentent une charge ionique qui est suffisante pour les stabiliser dans en dispersion dans un liquide, par exemple dans un solvant polaire. Le principe actif qui est situé à l'intérieur des particules peut être, par exemple, un composé pharmaceutique ou nutraceutique. Cette invention concerne également des formulations de médicaments contenant des phases hexagonales inversées et des phases cubiques inversées pouvant s'appliquer pour augmenter de manière significative la durée d'action dudit médicament et/ou pour conserver la même durée d'action et la même efficacité à une dose significativement plus basse.

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