Drug delivery via therapeutic hydrogels

Details Drug delivery via therapeutic hydrogels Drug delivery via therapeutic hydrogels

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61L 27/18 (2006.01) A61L 27/22 (2006.01) A61L 27/44 (2006.01) A61L 27/52 (2006.01) A61L 27/54 (2006.01) A61L 29/12 (2006.01) A61L 29/14 (2006.01) A61L 29/16 (2006.01) A61L 31/06 (2006.01) A61L 31/12 (2006.01) A61L 31/14 (2006.01) A61P 31/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2286644

The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in--dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.

L'invention concerne un véhicule servant à administrer un médicament depuis un substrat solide. Des hydrogels chargés d'agents thérapeutiques liposomes, tels que des antibiotiques, sont fixés de façon covalente à la surface de substrats, tels que des dispositifs médicaux à demeure, par exemple, des implants ou des cathéters. Cette invention est particulièrement utile pour le traitement et la prophylaxie d'infections favorisées par des films biologiques et souvent associées à l'utilisation de dispositifs médicaux à demeure.

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