Drug efflux pump inhibitor

Details Drug efflux pump inhibitor Drug efflux pump inhibitor

C - Chemistry, Metallurgy

12

Q

C12Q 1/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/06 (2006.01)

Patent

CA 2665516

Disclosed is a method for judging effectiveness of a drug efflux inhibitor against a microorganism, containing the steps of: (1) spreading a microorganism to be tested on a surface of an agar medium, then providing an antibacterial agent as a spot on the surface of the agar medium and culturing the microorganism; (2) determining the growth degree of the microorganism in a region of the agar medium containing the antibacterial agent; (3) determining a growth degree of the microorganism in a region of the agar medium containing both the antibacterial agent and a drug efflux inhibitor; and (4) judging that the drug efflux inhibitor is effective against the microorganism when the growth degree of the microorganism determined in step (2) is significantly higher than the growth degree of the microorganism determined in step (3).

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