Drug eluting radially expandable tubular stented grafts

A - Human Necessities – 61 – L

Patent

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A61L 31/10 (2006.01) A61F 2/06 (2006.01) A61L 27/34 (2006.01) A61L 27/50 (2006.01) A61L 27/58 (2006.01) A61L 31/14 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2465517

Drug eluting stented tubular grafts wherein the stent is coated with a coat comprising a composite of at least one biocompatible, pharmaceutically acceptable, bioerodible polymer and at least one therapeutic substance. The polymer may be a polyester. The therapeutic agent may include selective gene delivery vectors, sirolimus, actinomycin-D and paclitaxel. The stented grafts include an integrally stented embodiment and an internally stented embodiment. In each embodiment, the stent may be either self-expanding or pressure- expandable. Further, the stent may comprise a plurality of elements, wherein each said element comprises an undulating linear shape formed into a generally cylindrical configuration, and wherein each said element is connected to an adjacent neighbor element by at least one linear connector. A method for the treatment of cardiovascular disease by implantation of the stented graft, and an article of manufacture, comprising packaging material and the stented graft are also taught.

L'invention porte sur des greffes à stent tubulaire éluant les médicaments, le stent étant recouvert d'un revêtement comprenant un composite constitué d'au moins un polymère bioérodable, acceptable d'un point de vue pharmaceutique, biocompatible et d'au moins une substance thérapeutique. Le polymère peut être un polyester. L'agent thérapeutique peut comprendre des vecteurs d'administration de gènes sélectifs tels que le sirolimus, l'actinomycine D et le paclitaxel. Les greffes à stent tubulaire ont, selon les formes d'exécution, un stent intégré et un stent intérieur, le stent pouvant soit s'autodilater, soit se dilater sous pression. Le stent peut également comprendre une pluralité d'éléments ayant chacun une forme linéaire ondulante créée dans une configuration généralement cylindrique, chaque élément étant raccordé à un élément adjacent par au moins un raccord linéaire. L'invention porte, en outre, sur un procédé de traitement des maladies cardio-vasculaires par implantation de la greffe à stent, et sur un article de fabrication comprenant un matériau de conditionnement et la greffe à stent.

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