Drug-eluting stents for treating vulnerable coronary plaques

A - Human Necessities – 61 – L

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61L 31/16 (2006.01) A61L 31/10 (2006.01)

Patent

CA 2490898

A drug-eluting intravascular stent comprising an anti-restenosis agent covered by a biodegradable coating, and a method for treating vulnerable plaque in coronary vessels using said stent is disclosed. The biodegradable layer covers at least a portion of the drug-eluting layer of the stent, and is adapted to slowly erode over a preset period of time, preventing the release of therapeutic amounts of the anti-restenosis agent from the drug-eluting layer during the preset period. By delaying the release of the anti-restenosis agent, a thin layer of neointima will grow during the preset period. This tissue growth is sufficient to encapsulate the stent and cover the vulnerable plaque, but not significant enough to cause harmful restenosis or occlusion of the vessel. Once the biodegradable coating is eroded, the anti-restenosis agent begins release from the drug-eluting layer, and the progression of neointimal hyperplasia ceases.

L'invention concerne un stent intra-vasculaire à élution de médicament, comprenant un agent anti-resténose recouvert d'un revêtement biodégradable, et une méthode de traitement de la plaque vulnérable dans les vaisseaux coronaires au moyen dudit stent endovasculaire. La couche biodégradable recouvre au moins une partie de la couche d'élution de médicament du stent et est conçue pour s'éroder lentement sur une période prédéterminée, empêchant la libération de doses thérapeutiques de l'agent anti-resténose de la couche d'élution de médicament pendant la période prédéterminée. Le fait de retarder la libération de l'agent anti-resténose permet la formation d'une couche mince de néointima pendant la période prédéterminée. Cette formation de tissu est suffisante pour encapsuler le stent endovasculaire et recouvrir la plaque vulnérable, mais insuffisante pour induire une resténose ou une occlusion délétère du vaisseau. Une fois le revêtement biodégradable érodé, l'agent anti-resténose commence à être libéré de la couche d'élution de médicament et la progression de l'hyperplasie néointimale cesse.

LandOfFree

Say what you really think

Search LandOfFree.com for Canadian inventors and patents. Rate them and share your experience with other people.

Rating

Drug-eluting stents for treating vulnerable coronary plaques does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Drug-eluting stents for treating vulnerable coronary plaques, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Drug-eluting stents for treating vulnerable coronary plaques will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFCA-PAI-O-1341772

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.