Drug-enhanced adhesion prevention

A - Human Necessities – 61 – F

Patent

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A61F 13/00 (2006.01)

Patent

CA 2558785

The present invention includes methods for the inhibition of post-operative adhesion formation between tissue surfaces in a body cavity having been subjected to a surgical procedure, which methods involve administering Tranilast, or an analog thereof, directly to tissue surfaces in the body cavity in amounts and under conditions effective to inhibit formation of adhesions, and to delivery vehicles and compositions suitable for use for local, non-systemic administration of a drug to the body and directly to tissue within a body cavity having been subjected to a surgical procedure.

Méthodes destinées à inhiber la formation d'adhérences postopératoires entre des surfaces tissulaires dans une cavité corporelle ayant subi une intervention chirurgicale. Lesdites méthodes consistent à appliquer du tranilast, ou un analogue dudit composé, directement sur les surfaces tissulaires dans la cavité corporelle dans des quantités et dans des conditions efficaces pour inhiber la formation d'adhérences. La présente invention concerne également des vecteurs d'administration et des compositions destinées à être utilisées pour l'administration locale, non systémique au corps d'un médicament, directement sur les tissus dans la cavité corporelle ayant subi une intervention chirurgicale.

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