Drug flux enhancer-tolerant pressure sensitive adhesive...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/70 (2006.01) A61K 47/08 (2006.01) A61K 47/18 (2006.01) C08F 290/04 (2006.01)

Patent

CA 2171911

A drug flux enhancer-tolerant pressure sensitive adhesive composition is provided comprised of a mixture of (1) a percutaneous penetration enhancer to increase permeability of skin to transdermally administered pharmacologically active agents and (2) a macromer reinforced base polymer, said base polymer comprising a phase separated graft copolymer composition comprised of copolymerized monomers A and B to form a backbone polymer having polymeric moieties grafted thereto, wherein monomer A is a monomeric acrylic or methacrylic ester of a non-tertiary alcohol having from 1 to 14 carbon atoms, with the average number of carbon atoms being in the range of about 4 to 12, and a monomer B is a polar monomer which is copolymerizable with monomer A.

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