A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/675 (2006.01) A61K 31/66 (2006.01)
Patent
CA 2281937
Remedies for intramedullary diseases which are efficacious in correcting intramedullary biological balance, in particular, preventing inflammatory cellular infiltration and preventing increase in cell proliferation factors. These remedies contain as the active ingredient methanebisphosphonic acid derivatives, esters thereof, pharmaceutically acceptable salts thereof or hydrates of the same. Because of showing excellent therapeutic effects on intramedullary diseases, the above derivatives are expected as useful in preventing and treating intramedullary diseases such as rheumatoid arthritis, multiple myeloma and osteomyelitis. These compounds are also expected as useful in preventing and treating diseases of the hematopoietic system such as aplastic anemia and myelocytic leukemia.
L'invention porte sur des remèdes contre les maladies intramédullaires efficaces pour corriger l'équilibre biologique intramédullaire, et en particulier pour prévenir les infiltrations cellulaires inflammatoires et l'accroissement des facteurs d'accroissement des cellules. Lesdits remèdes comportent comme principe actif des dérivés de l'acide méthanebisphosphonique ou leurs esters, sels et hydrates pharmacocompatibles. En raison de leurs excellents effets thérapeutiques sur les maladies intramédullaires, lesdits dérivés s'avèrent utiles pour traiter la polyarthrite rhumatoïde, les myélomes multiples et l'ostéomyélite, et prévenir et traiter les maladies du système hématopoïétique telles que l'anémie aplasique ou la leucémie myéloïde.
Funaba Yuriko
Ito Masatoshi
Koike Junzo
Okazaki Seiji
Tanahashi Masahiko
Smart & Biggar
Toray Industries Inc.
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