Drug formulations having inert sealed cores

Details Drug formulations having inert sealed cores Drug formulations having inert sealed cores

A - Human Necessities

61

K

A61K 9/56 (2006.01) A61K 31/137 (2006.01) A61K 47/30 (2006.01) A61P 13/10 (2006.01)

Patent

CA 2693166

A drug composition comprising a coated bead is used in the manufacture of immediate release and/or controlled release drug compositions. In a specific embodiment, the bead includes an inert core of a water-soluble or water-swellable material, which has been coated with a seal layer formed from a non-polymeric hydrophobic material. The immediate and/or controlled release beads may be used to form tablets or capsules. A method of making the beads by sequential deposition of multiple layers on the inert cores is also described.

L'invention porte sur une composition de médicament comprenant une bille revêtue, qui est utilisée dans la fabrication de compositions de médicament à libération immédiate et/ou à libération contrôlée. Dans un mode de réalisation spécifique, la bille comprend un noyau inerte d'un matériau soluble dans l'eau ou gonflable par de l'eau, qui a été revêtu d'une couche d'étanchéité formée à partir d'un matériau hydrophobe non polymère. Les billes à libération immédiate et/ou contrôlée peuvent être utilisées pour former des comprimés ou capsules. L'invention porte également sur un procédé de fabrication des billes par dépôt séquentiel de multiples couches sur les noyaux inertes.

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