Drug nanoparticles from template emulsions

Details Drug nanoparticles from template emulsions Drug nanoparticles from template emulsions

A - Human Necessities

61

K

A61K 9/107 (2006.01) A61K 9/113 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2470533

A method for producing micron-sized or submicron-sized drugs is disclosed, which comprises preparing a template emulsion comprising water and a templating agent; preparing a drug-containing mixture comprising a drug substance; and combining the template emulsion with the drug-containing mixture to form a template emulsion loaded with drug particles. Drug particles prepared from this process are also disclosed. The resulting drug particles demonstrate faster dissolution rates and enhanced bioavailability as compared to unprocessed drug particles and particles prepared using other processes.

Procédé de production de médicaments ayant une taille de l'ordre du micron ou du submicron, qui consiste à préparer une émulsion matrice contenant de l'eau et un agent formant matrice, à préparer un mélange contenant une substance médicamenteuse et à combiner l'émulsion matrice avec le mélange contenant le médicament pour former une émulsion matrice chargée de particules de médicament. Des particules de médicament préparées selon ledit procédé sont également décrites. Les particules de médicament résultantes présentent des vitesses de dissolution plus rapides et une meilleure biodisponibilité par comparaison avec des particules de médicament non traitées et des particules préparées selon d'autres procédés.

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