Drug particles obtained by freezing onto a cold surface

Details Drug particles obtained by freezing onto a cold surface Drug particles obtained by freezing onto a cold surface

A - Human Necessities

61

K

A61K 9/19 (2006.01) A61K 9/16 (2006.01) A61K 31/00 (2006.01) A61K 31/38 (2006.01) B01D 9/00 (2006.01) F26B 5/06 (2006.01) F26B 17/28 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2513006

The present invention is a method for preparing micron-sized or submicron- sized drug particles comprising contacting a solution comprising a poorly water soluble drug substance and at least one freezable organic solvent with a cold surface so as to freeze the solution; and removing the organic solvent. The resulting particles are also disclosed, as are several embodiments of an apparatus that can be used in performing the method of the present invention.

L'invention concerne un procédé permettant de préparer des particules de médicaments de taille micrométrique ou submicrométrique, consistant à faire entrer en contact une solution contenant une substance médicamenteuse peu soluble dans l'eau, et au moins un solvant organique gelable, avec une surface froide de manière à congeler la solution, et à séparer le solvant organique. L'invention concerne également les particules résultantes, ainsi que diverses formes de réalisation d'un appareil permettant la mise en oeuvre du procédé décrit.

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