Drug release system

Details Drug release system Drug release system

A - Human Necessities

61

K

167/159

A61K 9/22 (2006.01) A61K 9/70 (2006.01) A61K 47/00 (2006.01) C08G 18/44 (2006.01) C08G 18/67 (2006.01)

Patent

CA 1266436

71727-6 ABSTRACT OF THE DISCLOSURE A drug releasing system in the form of a medical patch comprised of a drug dispensing polyurethane member as a matrix for a therapeutically effective amount of drug dispersed therein. The polyurethane of the drug dispensing or releasing member is a poly- urethane acrylic copolymer which is the reaction product of an oligomer of a diisocyanate, a glycol with a molecular weight between the range of 500-5000 molecular weight units and an acryl- yl chain terminator having a molecular weight between the range of 40-200 molecular weight units cured by actinic radiation. In its preferred embodiment, the foregoing drug releasing or dispensing member is incorporated into a medical patch or drug release system comprised of successive layers of an ultrathin polyurethane sub- strate, pressure sensitive adhesive, the above-described drug releasing member and optionally a second layer of adhesive. The drug release system of the present invention is biocompatible, oxygen and water vapor permeable, flexible and can incorporate a wide variety of drugs for a controlled, sustained release to the wearer.

506313

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