Drug resistance and multidrug resistance modulators

A - Human Necessities – 61 – K

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Details

A61K 31/495 (2006.01) C07D 241/04 (2006.01) C07D 295/073 (2006.01) C07D 295/088 (2006.01) C07D 295/092 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2272390

Drug and multidrug resistant modulators of Formula (C) where Z is selected from the group consisting of -S-, -S(O)w-, and -CH2-, where w is 1 or 2; and pharmaceutically acceptable salts or solvates thereof are described and claimed. Use of the new compounds in the preparation of pharmaceutical compositions is described and claimed. In addition, methods for treating drug and multidrug resistance in various diseases using a compound of this invention are described and claimed. Also, methods of enhancing oral bioavailability of a drug and methods of enhancing bioavailability of a drug to the brain using a compound of this invention are described and claimed.

L'invention concerne des modulateurs de la résistance aux médicaments et de la résistance multiple aux médicaments de la formule (C), ainsi que les sels et solvates de ces composés, acceptables sur le plan pharmaceutique. Dans cette formule, Z est choisi dans le groupe constitué par -S-, -S(O)¿w?- et -CH¿2?-, où w est 1 ou 2. On décrit et on revendique l'utilisation des nouveaux composés pour la préparation de compositions pharmaceutiques. D'autre part, on décrit et on revendique des méthodes de traitement pour surmonter la résistance aux médicaments et la résistance multiple aux médicaments, dans différentes maladies, faisant appel au composé de cette invention. Egalement, on décrit et on revendique des méthodes pour améliorer la biodisponibilité orale d'un médicament et des méthodes pour augmenter la biodisponibilité d'un médicament au niveau du cerveau, faisant appel au composé de cette invention.

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