Drug resistance-associated gene and use thereof

Details Drug resistance-associated gene and use thereof Drug resistance-associated gene and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/711 (2006.01) A61K 45/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/66 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2426621

By using an anticancer agent having a unique structure which is never been reported as being transported by a known transporter protein capable of imparting tolerance to cancer cells, a cell line tolerant to this anticancer agent is established. Then a cDNA encoding a protein which is expressed at a high level in this tolerant strain is successfully isolated. Use of this gene together with the an anticancer agent and to select an anticancer agent which can be administered to patients with cancer. Moreover, a candidate compound for an inhibitor of the transporter can be screened thereby. By using a combination of the inhibitor thus obtained with the above-described anticancer agent, the sensitivity of cancer cells tolerant to the anticancer agent can be enhanced.

Selon l'invention, l'utilisation d'un agent anticancéreux ayant une structure unique qui n'est jamais signalée comme étant transportée par une protéine transporteuse connue capable de conférer une tolérance aux cellules cancéreuses permet d'établir une ligne cellulaire tolérante à cet agent anticancéreux. Ensuite, on isole avec succès un ADNc codant pour une protéine exprimée à un niveau élevé dans cette souche tolérante. On utilise ce gène ainsi que l'agent anticancéreux et sélectionner un agent anticancéreux pouvant être administré au patient. De plus, un composé candidat pour un inhibiteur du transporteur peut ainsi être analysé. L'utilisation d'une combinaison de l'inhibiteur ainsi obtenu avec l'agent anticancéreux décrit ci-dessus permet de renforcer la sensibilité des cellules cancéreuses tolérantes à l'agent anticancéreux.

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