Drug resistance-conferring protein, antibodies reactive...

C - Chemistry – Metallurgy – 12 – P

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C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2102256

Abstract Monoclonal and genetically engineered antibodies which react with P190, a protein associated with anthracycline resistance are disclosed. The P190 reactive antibodies are useful in determining anthracycline resistance and purification of P190. P190 and antibodies reactive therewith are useful for screening P190 antagonists.

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