Drug screening and diagnosis based on paracrine tubular...

Details Drug screening and diagnosis based on paracrine tubular... Drug screening and diagnosis based on paracrine tubular...

A - Human Necessities

61

K

A61K 38/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/493 (2006.01) G01N 33/50 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2342921

The present invention relates to a method for screening drugs for use in treating hypertension using the tubular renin-angiotensinogen system identified by the present invention. The invention further relates to a method to diagnose sodium status and sensitivity in an individual by measuring urinary angiotensinogen or angiotensin-I.

L'invention a trait à un procédé de criblage de médicaments utiles pour traiter l'hypertension au moyen du système de rénine-angiotensinogène tubulaire identifié par la présente invention. L'invention concerne en outre un procédé permettant de diagnostiquer un état pathologique lié au sodium et une sensibilité au sodium chez un sujet par la mesure d'angiotensinogène ou d'angiotensine I urinaire.

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