Drug-surfactant complexes for sustained release

Details Drug-surfactant complexes for sustained release Drug-surfactant complexes for sustained release

A - Human Necessities

61

K

A61K 9/52 (2006.01)

Patent

CA 2618076

The invention involves sustained-release pharmaceutical compositions containing a water-soluble ionic small molecule pharmaceutical agent complexed with an oppositely charged surfactant, particularly a natural bile surfactant. The complexes are sustained- release ionic complexes. The complexes release the ionic pharmaceutical agents into aqueous solution slowly and with zero- order kinetics. Thus, they can be formulated into sustained-release pharmaceutical compositions. The invention also provides sustained- release pharmaceutical compositions containing a water-soluble ionic small molecule pharmaceutical agent complexed with an oppositely charged non-surfactant amphipathic substance, particularly benzathine or pamoate.

L'invention concerne des compositions pharmaceutiques à libération prolongée qui renferment un agent pharmaceutique à petites molécules ioniques soluble dans l'eau, formant un complexe avec un tensioactif de charge opposée, en particulier un tensioactif à base de bile naturelle. Ces complexes constituent des complexes ioniques à libération prolongée. Lesdits complexes libèrent lentement les agents pharmaceutiques ioniques dans une solution aqueuse, avec une cinétique d'ordre 0. Ils peuvent par conséquent être formulés en compositions pharmaceutiques à libération prolongée. L'invention concerne aussi des compositions pharmaceutiques à libération prolongée qui renferment un agent pharmaceutique à petites molécules ioniques soluble dans l'eau, formant un complexe avec une matière amphipathique de charge opposée autre qu'un tensioactif, en particulier la benzathine ou le pamoate.

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