Drug targeting system, method for preparing same and its use

Details Drug targeting system, method for preparing same and its use Drug targeting system, method for preparing same and its use

A - Human Necessities

61

K

A61K 9/52 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/12 (2006.01)

Patent

CA 2184242

A novel method of delivering drugs and diagnostics across the blood-brain barrier or blood-nerve barrier is disclosed. Drugs or diagnostic agents are incorporated into nanoparticles which have been fabricated in conventional ways. These nanoparticles are then coated with additional surfactant and given to the body of animals or humans. This allows drugs or diagnostic agents to cross the blood-brain barrier (bbb) to achieve one or more of the following benefits: (1) reducing the dose of a therapeutic drug or diagnostic agent which, when given peripherally, maintains the biological or diagnostic potency in the nervous system, (2) allowing drugs that normally do not cross the bbb to penetrate into the nervous system, and (3) reducing the peripheral side effects by increasing the relative amount of the drug reaching the brain.

L'invention se rapporte à un nouveau système de libération de médicaments et d'agents de diagnostic à travers la barrière hémato-encéphalique ou la barrière hémato-nerveuse. On incorpore des médicaments ou des agents de diagnostic dans des nanoparticules fabriquées de manière classique, puis on enrobe ces nanoparticules de tensioactifs additionnels, et on les administre à un corps humain ou animal. Ce procédé de préparation permet aux médicaments ou aux agents de diagnostic de traverser la barrière hémato-encéphalique, avec les avantages suivants: (1) réduction de la dose thérapeutique du médicament ou de l'agent de diagnostic qui, lorsqu'ils sont administrés par voie périphérique, maintiennent le potentiel biologique ou diagnostique dans le système nerveux, (2) passage dans le système nerveux de médicaments ne traversant généralement pas la barrière hémato-encéphalique, et (3) réduction des effets secondaires périphériques par augmentation de la quantité relative de médicament atteignant le cerveau.

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