Drug targets in candida albicans

Details Drug targets in candida albicans Drug targets in candida albicans

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) C07K 14/40 (2006.01) C07K 16/14 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2353525

The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.

La présente invention concerne l'identification de gènes provenant de Candida albicans, ou de leurs fragments fonctionnels, indispensables au développement et à la division cellulaire, ces gènes pouvant être utilisés comme cibles médicamenteuses sélectives pour traiter les infections associées aux Candida albicans. En outre, cette invention concerne de nouvelles séquences d'acides nucléiques provenant de Candida albicans codant les polypeptides indispensables à la croissance des Candida albicans. De plus, cette invention concerne des procédés d'identification de composés antifongiques qui inhibent le développement des champignons ou des levures.

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