Drug therapy

Details Drug therapy Drug therapy

C - Chemistry, Metallurgy

07

C

C07C 333/04 (2006.01) A61K 38/43 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) C07C 271/54 (2006.01) C07C 327/48 (2006.01) C07C 333/20 (2006.01) C07C 391/02 (2006.01) C07D 209/20 (2006.01) C07D 213/72 (2006.01) C07D 213/89 (2006.01) C07D 233/64 (2006.01) C07D 239/38 (2006.01) C07D 475/08 (2006.01) C07H 15/203 (2006.01)

Patent

CA 2239203

A therapeutic system comprising: (a) a compound comprising a target cell-specific portion and a portion capable of converting a substance into another substance; and (b) a molecule capable of substantially inhibiting the conversion of said substance, or a precursor of said molecule. In one particularly preferred embodiment said other substance is cytotoxic and said substance is substantially non-cytotoxic, the system further comprising said substance. In a second particularly preferred embodiment said substance, in its native state, is able to inhibit the effect of a cytotoxic agent and said other substance has less effect against said cytotoxic agent, the system further comprising (a) a cytotoxic agent and (b) said substance.

Système thérapeutique constitué : a) d'un composé renfermant une fraction cible spécifique pour la cellule et une fraction pouvant convertir une substance en une autre substance; b) d'une molécule pouvant pratiquement inhiber la conversion de ladite substance, ou d'un précurseur de ladite molécule. Dans une version particulièrement privilégiée, ladite autre substance est cytotoxique et ladite substance est pratiquement non cytotoxique, le système renfermant ladite substance. Dans une deuxième version particulièrement privilégiée, ladite substance peut, dans son état initial, inhiber l'effet d'un agent cytotoxique, et ladite autre substance a moins d'effet contre ledit agent cytotoxique, le système comprenant a) un agent cytotoxique et b) ladite substance.

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