Drug transport and delivery system

Details Drug transport and delivery system Drug transport and delivery system

C - Chemistry, Metallurgy

07

K

C07K 5/10 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 47/48 (2006.01) A61P 19/02 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 5/08 (2006.01)

Patent

CA 2490354

Described are tripeptides or tetrapeptides comprising a proteolytic enzyme cleavable amino acid moiety as a drug or pharmacologically active site or pharmacologically active group binding, transport by blood cells and delivery system as well as to the transport and delivery system coupled drugs. Such transport and delivery system is especially favorable for the treatment of diseases that lead to an enhanced activity of proteolytic enzymes such as cancer, arthritis, or are blood cell related.

La présente invention concerne des tripeptides ou des tétrapeptides comprenant un groupe d'acide aminé clivable par enzyme protéolytique qui sert de système de transport par cellules sanguines et de distribution de médicament, de site à activité pharmacologique ou de liaison de groupe à activité pharmacologique, ainsi que les médicaments couplés à ce système de transport et de distribution. Un tel système de transport et de distribution est particulièrement adapté au traitement de maladies menant à une plus grande activité d'enzymes protéolytiques, telles que le cancer ou l'arthrite, ou de maladies liées aux cellules sanguines.

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