Drugs and prodrugs useful for the treatment of energy...

A - Human Necessities – 61 – K

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A61K 31/4725 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2587690

The use of a compound of formula (I) an isomer thereof, a prodrug of said compound or isomer, or a pharmaceutically acceptable salt of said compound, isomer or prodrug, in the manufacture of a medicament for the palliative, prophylactic or curative treatment of negative energy balance in ruminants. The use of a compound of formula 1, in the manufacture of a medicament for the palliative, prophylactic or curative treatment of ruminant disease associated with negative energy balance in ruminants, wherein, preferably, the ruminant disease associated with negative energy balance in ruminants is selected from fatty liver syndrome, dystocia, immune dysfunction, impaired immune function, toxification, primary ketosis, secondary ketosis, downer cow syndrome, indigestion, inappetence, retained placenta, displaced abomasum, mastitis, (endo-)-metritis, infertility, low fertility, and lameness.

Cette invention concerne l~utilisation d~un composé de formule (I), un isomère de celui-ci, un promédicament dudit composé ou isomère ou un sel pharmaceutiquement acceptable dudit composé, isomère ou promédicament, dans la fabrication d~un médicament destiné au traitement palliatif, prophylactique ou curatif d~un bilan énergétique négatif chez des ruminants. Cette invention concerne également l'utilisation d~un composé de formule 1 pour la fabrication d~un médicament destiné au traitement palliatif, prophylactique ou curatif d~une maladie de ruminant associée à un bilan énergétique négatif, cette maladie étant de préférence sélectionnée parmi la stéatose hépatique, la dystocie, le dysfonctionnement immunitaire, l~altération de la fonction immunitaire, la contamination, la cétose primaire, la cétose secondaire, le syndrome de la vache couchée, l~indigestion, l~anorexie, la rétention du placenta, le déplacement de la caillette, la mastite, l~(endo)métrite, l'infertilité, les troubles de la fertilité et la claudication.

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