A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 31/56 (2006.01)
Patent
CA 2649940
The invention relates to methods to treat specified clinical disorders such as hyperglycemia, type 2 diabetes, arthritis and multiple sclerosis. The invention also provides methods to identify and characterize drugs, which are characterized in part by eliciting a variable biologic or therapeutic effect on a biomolecule at one time and relative normalization of the biomolecule at another time point. Compounds include 17.alpha.-ethynylandrost-5-ene-3.beta.,7.beta., 17.beta.-triol or androst-5-ene-3.beta.,4.beta., 16.alpha., 17.beta.-tetrol, which can be used as reference standards to facilitate assessing and characterizing such candidate drugs.
L'invention concerne des procédés permettant de traiter des troubles cliniques particuliers tels que l'hyperglycémie, le diabète de type 2, l'arthrite et la sclérose en plaques. Par ailleurs, l'invention concerne des procédés d'identification et de caractérisation de médicaments, caractérisés en partie par le déclenchement d'un effet biologique ou thérapeutique variable dans une biomolécule à un moment donné, et la normalisation relative de la biomolécule à un autre moment. Les composés comprennent 17.alpha.-éthynylandrost-5-ene-3.beta.,7.beta., 17.beta.-triol ou androst-5-ene-3.beta.,4.beta., 16.alpha., 17.beta.-tetrol, lesquels peuvent être utilisés comme standards de référence pour faciliter l'évaluation et la caractérisation de tels médicaments.
Frincke James M.
Reading Christopher L.
Harbor Biosciences Inc.
Hollis-Eden Pharmaceuticals Inc.
Sim & Mcburney
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