Drugs augmenting nkt cells

A - Human Necessities – 61 – K

Patent

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A61K 31/47 (2006.01) A61K 31/4704 (2006.01) C07C 231/02 (2006.01) C07C 233/54 (2006.01) C07C 327/42 (2006.01) C07D 215/56 (2006.01)

Patent

CA 2312406

Drugs inhibiting autoimmune responses and/or potentiating normal immune responses through the augmentation of NKT cells, characterized by containing as the active ingredient compounds represented by general formula (I) or pharmaceutically acceptable salts thereof; and a novel process for synthesizing these compounds, wherein R1 represents hydrogen or halogeno; R2 represents hydroxy; R3 represents lower alkyl; R4 represents lower alkyl; R5 represents hydrogen or lower alkoxy; and Z represents O or S.

L'invention concerne des médicaments inhibant les réponses autoimmunes et/ou renforçant des réponses immunitaires normales par augmentation des cellules NKT, ces médicaments se caractérisant par le fait qu'ils contiennent comme ingrédients actifs des composés représentés par la formule générale (I), ou des sels de ces composés acceptables du point de vue pharmaceutique. L'invention concerne également un nouveau procédé de synthèse de ces composés. Dans la formule selon l'invention, R?1¿ représente un hydrogène ou un halogène; R?2¿ représente un hydroxy; R?3¿ représente un alkyle inférieur; R?4¿ représente un alkyle inférieur; R?5¿ représente un hydrogène ou un alcoxy inférieur; et Z représente O ou S.

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