A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) C07D 231/20 (2006.01) C07D 231/22 (2006.01) C07D 231/26 (2006.01) C07D 231/28 (2006.01) C07D 231/56 (2006.01)
Patent
CA 2460141
It is intended to provide drugs for treating and/or preventing ischemic diseases which are safe and have little side effects. Namely, drugs comprising a combination of a tissue plasminogen activator and a pyrazolone derivative of the following formula (I): (see formula I) wherein R1 represents hydrogen atom, an aryl group, an alkyl group having 1 to 5 carbon atoms or an alkoxycarbonylalkyl group having 3 to 6 carbon atoms in total; R2 represents hydrogen atom, an aryloxy group, an arylmercapto group, an alkyl group having 1 to 5 carbon atoms or a hydroxyalkyl group having 1 to 3 carbon atoms; or R1 and R2 is coupled together to form an alkylene group having 3 to 5 carbon atoms; and R3 represents hydrogen atom, an alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 5 to 7 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, benzyl group, a naphthyl group or phenyl group, or a phenyl group substituted with 1 to 3 substituents, which may be the same or different and selected from the group consisting of an alkyl group having 1 to 5 carbon atoms, an alkoxy group having 1 to 5 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms in total, an alkylmercapto group having 1 to 3 carbon atoms, an alkylamino group having 1 to 4 carbon atoms, a dialkylamino group having 2 to 8 carbon atoms in total, a halogen atom, trifluoromethyl group, carboxyl group, cyano group, hydroxyl group, nitro group, amino group and acetamido group, or pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof.
La présente invention concerne des médicaments destinés au traitement et/ou à la prévention d'affections ischémiques. Ces médicaments sont inoffensifs et n'ont pratiquement pas d'effets secondaires. En l'occurrence, l'invention concerne des médicaments associant un antithrombotique à un dérivé pyrazolone défini dans la description ou l'un de ses sels pharmaceutiquement admis.
Eguchi Jyunichi
Kurita Katsumi
Tanaka Masahiko
Tanaka Tadashi
Yamada Keiichi
Kirby Eades Gale Baker
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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