Drugs containing galectin 9

Details Drugs containing galectin 9 Drugs containing galectin 9

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 5/38 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2514108

Galectin 9 exerts various functions depending on its localizations. On the other hand, galectin 9 is expected as participating in various biological functions. Thus, it has been required to clarify the detailed biological activities of galectin 9 and develop galectin 9-related techniques including development of drugs. Human galectin 9 shows a cytotoxic activity and an apoptosis-inducing activity on tumor cells but shows neither cytotoxic activity nor apoptosis-inducing activity on normal cells. Therefore, it is possible to employ galectin 9 protein, a galectin 9 agonist, a galectin 9 antagonist, an anti-galectin 9 binding protein antibody, an anti-galectin 9 binding sugar chain antibody, a galectin 9-producing,releasing or inducing substance, etc. as an antitumor agent, an antiallergic agent, an immunosuppressant, a drug for autoimmune diseases, an antiinflammatory agent and an active ingredient as a substitute for corticosteroid hormone.

Galectine 9 exerce différentes fonctions selon ses localisations. D'autre part, on pense que galectine 9 participe à différentes fonctions biologiques. Il est donc nécessaire de clarifier les activités biologiques détaillées de galectine 9 et de développer des techniques associées à galectine 9 y compris la création de médicaments. Galectine 9 humaine démontre une activité cytotoxique et une activité induisant l'apoptose sur des cellules tumorales mais ne démontre ni activité cytotoxique, ni activité induisant l'apoptose sur des cellules normales. Il est, par conséquent, possible d'utiliser une protéine de galectine 9, un agoniste de galectine 9, un antagoniste de galectine 9, un anticorps de protéine de liaison anti-galectine 9, un anticorps de chaîne de sucre de liaison anti-galectine 9, une substance induisant, libérant ou produisant galectine 9 en tant qu'agent antitumoral, agent anti-allergique, immunosuppresseur, médicament contre des maladies auto-immunes, agent anti-inflammatoire et ingrédient actif sous forme de substitut d'hormone corticostéroïde.

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