C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 1/16 (2006.01) C12N 15/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2592461
A Gpbar1-deficient mouse is constructed and it is examined whether or not Gpbar1 participates in the regulation of bile acid homeostasis and lipid metabolism. As a result, the total bile acid pool is decreased in the Gpbar1- deficient mouse without showing any change in the fecal bile acid level. A female Gpbar1-deficient mouse having been fed with a high fat feed shows a significant increase in body weight compared with a wild type mouse, which is caused by an increase in fat. These facts suggest that Gpbar1 contributes to the regulation of bile acid homeostasis and lipid metabolism.
Selon l~invention, une souris est rendue Gpbar1-déficiente et examinée en vue de savoir si Gpbar1 participe ou non à la régulation de l~homéostasie des acides biliaires et du métabolisme lipidique. Il en résulte une baisse des acides biliaires totaux chez la souris Gpbar1-déficiente sans présenter aucune modification du niveau des acides biliaires fécaux. Par ailleurs, une souris femelle Gpbar1-déficiente ayant été nourrie d~une ration à teneur élevée en matières grasses affiche une augmentation significative du poids corporel, due à une augmentation de la masse adipeuse, par rapport à une souris de type sauvage. Ces éléments suggèrent que Gpbar1 contribue à réguler l~homéostasie des acides biliaires et le métabolisme lipidique.
Maruyama Takaharu
Suzuki Jun
Tamai Yoshitaka
Tanaka Kenichi
Banyu Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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