A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/53 (2006.01) A61K 31/185 (2006.01) A61K 31/381 (2006.01) A61K 31/403 (2006.01) A61K 31/4164 (2006.01) A61K 31/4196 (2006.01) A61K 31/454 (2006.01) A61K 31/502 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61P 25/00 (2006.01) C12Q 1/00 (2006.01)
Patent
CA 2493883
The present invention is directed to a compound for treatment or prevention of brain injury caused by diseases such as cerebrovascular disorder, brain degenerative disease and demyelinating disease and a method for screening the same. Brain injury in which prostaglandin D2 participates is treated or prevented by inhibition of hematopoietic prostaglandin D synthase induced in microglia cell or macrophage of a brain injury area by diseases such as cerebrovascular disorder, brain degenerative disease or demyelinating disease or by the inhibition of activation of prostaglandin D receptor expressed in astroglia cell around the injured area. The invention also provides a method of testing those pharmaceutical substances using a transgenic mouse in which human hematopoietic prostaglandin D synthase is expressed in large amounts.
L'invention concerne un composé destiné à traiter ou à prévenir un trouble cérébral tel qu'un trouble cérébrovasculaire, une maladie de dégénérescence cérébrale ou de démyélinisation ainsi qu'un procédé de criblage de ce composé. Un trouble cérébral (par exemple, trouble ou maladie cérébrovasculaire, de dégénérescence ou de démyélinisation) dans lequel la prostaglandine D¿2? participe est traité ou prévenu par inhibition de la synthétase de prostaglandine D hématopoïétique induite dans les cellules microgliales ou dans les macrophages du site atteint ou par inhibition de l'activation du récepteur de prostaglandine D exprimé dans les cellules astrogliales entourant le site atteint. L'invention concerne aussi un procédé de tests d'un tel principe actif pharmaceutique avec l'utilisation d'une souris transgénique présentant une surexpression de la synthétase de prostaglandine D hématopoïétique humaine.
Aritake Kosuke
Eguchi Naomi
Kadoyama Keiichi
Sato Yo
Taniike Masako
Japan Science And Technology Agency
Kirby Eades Gale Baker
Osaka Bioscience Institute
Shionogi & Co. Ltd.
Taiho Pharmaceutical Co. Ltd.
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